Medicinal Chemistry

Nuclear magnetic resonance (NMR) technology provides data that characterize the three-dimensional structure of small molecules and proteins, either alone or bound to biological targets. It is particularly important in the identification of drug metabolites. The NMR team at the Merck Frosst Centre for Therapeutic Research was involved in the identification of the majority of the metabolites generated during the development of SINGULAIR^® (montelukast sodium), which was critical in preventing potential problems in the drug development process.

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With five state-of-the-art high field NMR spectrometers ranging in frequency from 600 to 400 MHz, and the facilities to perform four-dimensional protein NMR experiments and to couple a high-performance liquid chomatographer (HPLC) or Gilson^® liquids handler to an NMR spectrometer, Merck Frosst is at the leading edge of this technology.

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